Amniotic membrane transplantation for ocular surface burns / Transplante de membrana amniótica em queimaduras da superfície ocular

ABSTRACT Objective: To analyze the morphological and functional long-term outcomes of amniotic membrane transplantation after ocular surface chemical burns. Methods: This prospective study analyzed 7 patients who suffered from severe ocular surface burn and underwent amniotic membrane transplantation from 2015 to 2020 in Hospital de Clínicas - Universidade Federal do Paraná. Results: Out of the seven patients, six (85.7%) suffered unilateral burn and one (14.3%) suffered bilateral burn. Five of them had alkali burns (71.4%), one had acid burn (14.3%) and one suffered gunpowder fireworks burn (14.3%). Mean age was 29.4 years (±standard deviation 13.3, range 14.0 to 47.0 years). Mean visual acuity at first presentation was 1.83±0.79 logMAR (0.015 decimal) and mean VA after a follow-up of 1 year was 0.85±0.70 logMAR (0.141 decimal). The visual acuity significantly improved from 1.83±0.79 to 0.85±0.70 logMAR (p<0.05). Conclusion: Amniotic membrane transplantation is an effective adjunctive treatment in the management of ocular surface chemical burns with potential to improve the final vision outcome.

RESUMO Objetivo: Analisar os resultados morfológicos e funcionais a longo prazo do transplante de membrana amniótica após queimaduras químicas da superfície ocular. Métodos: Foi realizado um estudo prospectivo com análise de sete pacientes que sofreram queimaduras graves da superfície ocular e foram submetidos a transplante de membrana amniótica no período de 2015 a 2020 no Hospital de Clínicas da Universidade Federal do Paraná. Resultados: Dos sete pacientes, seis (85,7%) sofreram queimadura unilateral e um (14,3%) sofreu queimadura bilateral. Cinco deles sofreram queimaduras por álcali (71,4%), um por ácido (14,3%) e um por pólvora de fogo de artifício (14,3%). A média de idade foi de 29,4 anos (±desvio-padrão de 13,3, intervalo de 14,0 a 47,0 anos). A acuidade visual média na primeira apresentação foi de 1,83±0,79 logMAR (0,015 decimal) e, após 1 ano de seguimento, foi de 0,85±0,70 logMAR (0,141 decimal). A acuidade visual melhorou significativamente, de 1,83±0,79 para 0,85±0,70 logMAR (p<0,05). Conclusão: O transplante de membrana amniótica é um tratamento adjuvante eficaz no manejo de queimaduras químicas da superfície ocular com potencial para melhorar a visão final.

Demographic profile and clinical characteristics of patients presenting with acute ocular burns

Purpose: To study and compare the demographic and clinical profile of acute ocular burns (AOB) in children and adults. Methods: This retrospective case series included 271 children (338 eyes) and 1300 adults (1809 eyes) who presented to two tertiary eye care centers within one month of sustaining AOB. Data regarding demographics, causative agents, severity of injury, visual acuity (VA), and treatment were collected and analyzed. Results: Males were more commonly affected particularly among adults (81% versus 64%, P < 0.00001). Among children, 79% sustained domestic injuries, whereas 59% of adults had work?place injuries (P < 0.0001). Most cases were due to alkali (38%) and acids (22%). Edible lime (chuna, 32%), superglue (14%), and firecrackers (12%) in children, and chuna (7%), insecticides, lye, superglue (6% each), toilet cleaner (4%) and battery acid (3%) in adults, were the main causative agents. The percentage of cases with Dua grade IV?VI was greater in children (16% versus 9%; P = 0.0001). Amniotic membrane grafting and/or tarsorrhaphy were needed in 36% and 14% of affected eyes in children and adults, respectively (P < 0.00001). The median presenting VA was logMAR 0.5 in children and logMAR 0.3 in adults (P = 0.0001), which improved significantly with treatment in both groups (P < 0.0001), but the final VA in eyes with Dua grade IV?VI burns was poorer in children (logMAR 1.3 versus logMAR 0.8, P = 0.04). Conclusion: The findings clearly delineate the at?risk groups, causative agents, clinical severity, and treatment outcomes of AOB. Increased awareness and data?driven targeted preventive strategies are needed to reduce the avoidable ocular morbidity in AOB

Outcome Of LSCT With And Without AMT In Partial LSCD

Purpose – To compare the outcomes of LSCT with and with out AMT in patients of partial LSCD following chemical burns. Method – 32 eyes with unilateral LSCD were randomized into two groups. Group A included 16 eyes who underwent LSCT with AMT while group B included 16 eyes who underwent LSCT alone at a tertiary hospital. Outcome were measured in terms of improvement of visual acuity , corneal clarity, vascularization and symblepharon reduction. Patients were followed up at end of 1st week,1 month and 3rd month,6th month and 1 year. There wasResults – improvement of visual acuity in both groups. Also both group shows reduction in symblepharon score and corneal vascularization. Both group shows improvement in corneal clarity. Both surgical technique are usefulConclusions- treatment modalities in patients with partial LSCD following ocular chemical injury.

Risk of induction of corneal neovascularization with topical erythropoietin: an animal safety study

Purpose: To evaluate the pro-angiogenic effect of topical erythropoietin on cornea in chemical burn-injured rabbit eyes. Methods: The corneal alkali-burn injury was induced in 10 eyes of 10 rabbits using filter paper saturated with 1.0 mol sodium hydroxide. The eyes were categorized into the treatment group (n = 5) that received topical erythropoietin (3000 IU/mL) every 8 hr for one month versus the control group (n = 5) that received normal saline every 8 hr for one month. All eyes were treated with topical ciprofloxacin every 8 hr until corneal re-epithelialization was complete. Corneal epithelial defects, stromal opacity, and neovascularization were evaluated after the injury. At the conclusion of the study, the rabbits were euthanized and their corneas were submitted to histopathological examination. Results: Baseline characteristics including the rabbits' weight and the severity of corneal injury were comparable in two groups. Time to complete corneal re-epithelialization was 37 days in the treatment group and 45 days in the control group (P = 0.83). There was no significant difference between the groups in the rate of epithelial healing or corneal opacification. Clinical and microscopic corneal neovascularization was observed in one eye (20%) in the treatment group and two eyes (40%) in the control group (P = 0.49). Conclusion: Recombinant human erythropoietin administered topically did not induce vessel formation in rabbit corneas after chemical burn.

Chemical injury to eye- A case report

Chemical burns represent blinding ocular injuries and constitute an ocular emergency requiring immediate assessment and initiation of treatment. The majority of patients are of young age groups and exposure will occur anywhere as an accident and in association with criminal assaults too. Alkali injuries occur more frequently. Chemical injuries of the eye produce extensive damage to the conjunctiva, cornea, anterior segment and limbal stem cells resulting in unilateral or bilateral visual impairment. This article reviews the emergency management to improve the prognosis of patients with chemical injuries

O uso da abdominoplastia reversa para o tratamento de queimadura química em região toracoabdominal / The use of reverse abdominoplasty for treatment of chemical burn in the thoracoabdominal region

A queimadura química é um desafio devido à sua agressividade em comparação com as queimaduras térmicas. A profundidade e extensão das lesões em diferentes áreas do corpo nos levam a buscar diferentes possibilidades para auxiliar no melhor tratamento do paciente. Foi proposto, a partir da técnica cirúrgica abdominoplastia reversa, um retalho cutâneo que pudesse reduzir a área exposta de uma paciente vítima de queimadura química. O resultado foi satisfatório, reduziu tempo de tratamento, cirúrgico e de internação da paciente, evidenciando uma ferramenta importante de reconstrução toracoabdominal.

Chemical burn is a challenge owing to its severity compared to thermal burns. The depth and extent of lesions in different areas of the body lead us to look for different possibilities for the best treatment of the patient. A reverse abdominoplasty surgical technique was proposed; this involves a skin flap that could reduce the exposed area of a chemical burn. The result was satisfactory, reducing the patient's treatment, surgical and hospitalization time, highlighting the proposed technique as an important tool for thoracoabdominal reconstruction.

Ocular chemical burns from accidental exposure to topical dermatological medicinal agent

We report a case of accidental ocular chemical injury by self-medication with a single application of a topical ayurvedic medication containing salicylic acid, phenol, and tincture iodine, which is being used in developing countries for treatment of various dermatological conditions.

Desenlaces en pacientes operados con queratoprótesis boston tipo 1 en un centro oftalmológico especializado en la ciudad de Medellín / Outcomes in patients with boston type 1 keratoprosthesis in a specialized center in Medellín

Objetivo: reportar las características y descenlaces de pacientes con queratoprótesis Boston tipo 1. Diseño: estudio observacional descriptivo de corte transversal. Método: se incluyeron los pacientes operados con queratoprótesis Boston tipo 1 residentes en Colombia, mayores de 17 años, sin queratoprótesis previas y que tuviera más de 6 meses de seguimiento, para un total de 39 ojos de 39 pacientes. La cirugía se indicó en los casos con o sin queratoplastia previa que tuvieran agudeza visual (AV) igual o inferior a cuenta dedos y déficit de limbo bilateral o vascularización corneal profunda en más de 3 cuadrantes. Se recolectó y analizó la información de la historia clínica en forma retrospectiva y prospectiva. Las variables principales fueron: agudeza visual, retención del dispositivo y complicaciones. Se realizó un análisis univariado presentando los resultados en frecuencias absolutas y porcentajes para las variables categóricas y para las variables cuantitativas como promedio y desviación estándar (DE) si tienen distribución normal o como mediana y rango intercuartil si no tienen distribución normal. Resultados: La mediana de seguimiento fue de 53.5 meses (rango 6 meses a 10 años). La mayoría de pacientes (66.7%) habían tenido previamente queratoplastia penetrante. El diagnóstico de base fue en 53.8% condiciones no inflamatorias yen 46.2% condiciones inflamatorias. La AV preoperatoria en todos los ojos estaba entre percepción de luz y cuenta dedos; posterior a la cirugía el 97.4% tuvieron mejoría de la AV. Para el fi nal del seguimiento la AV permaneció mejor que la preoperatoria en 53.8%, fue igual a esta en 17.94% y peor que esta en 28.2%. Hubo necrosis periprostética en 28.2%, y 38.5% tuvieron recambio del dispositivo. Al final del seguimiento 89.7% de los pacientes tenían una queratoprótesis in-situ. Conclusión: la queratoprótesis Boston tipo 1 es una opción viable para mejorar la AV en pacientes con trasplantes de córnea fallidos o en quienes se prevé alta tasa de fallo o rechazo de este. En la gran mayoría de los pacientes se logra mejoría inicial significativa de la AV, la cual se mantiene al final del seguimiento en más de la mitad de ellos. Refinamientos progresivos en la técnica quirúrgica y el manejo postoperatorio disminuirán las complicaciones que llevan a la perdida visual progresiva

Purpose: to report characteristics and outcomes in patients with Boston type 1 keratoprosthesis. Design: observational descriptive cross-sectional study. Method: Patients with Boston type 1 queratoprosthesis who were living in Colombia, 17 years or older, without previous keratoprosthesis and with more than 6 months follow up were included, for a fi nal of 39 eyes from 39 patients. Surgery was indicated for those with or without previous keratoplasty who had visual acuity (VA) of counting fi ngers or worse and bilateral limbal stem cell deficiency or deep corneal vascularization in more than 3 quadrants. Information was collected retrospectively and prospectively from medical registries and was analyzed. Main variables were: visual acuity, device retention and complications. An univariate analysis was conducted and results are presented in absolute frequencies and percentages for categoric variables and for quantitative variables in average and standard deviation (SD) if they have normal distribution and in median and interquartile range if they do not have normal distribution. Results: Median follow up was 53.5 months (range 6 months to 10 years). Most patients (66.7%) had previous penetrating keratoplasty. Baseline diagnoses were in 53.8% non-infl ammatory conditions and in 46.2% inflammatory conditions. Preoperative VA ranged between light perception and counting fingers in all eyes; aft er surgery 97.4% had improvement in VA. By the end of follow up VA remained better than preoperative in 53.8%, was the same as preoperative in 17.94% and worse than preoperative in 28.2%. There was periprosthetic necrosis in 28.2%, and 38.5% had keratoprothesis exchange. At the end of follow up 89.7% of patients had a keratoprosthesis in-situ. Conclusion: Boston type 1 keratoprosthesis is a viable option to improve VA in patients with previously failed corneal transplants or in cases that anticipate bad prognosis for keratoplasty. In most patients there was a signifi cant initial improvement in vision, and more than half of them retained better than initial VA on their last follow up. Further refinements in surgical technique and postoperative care would decrease complications that lead to progressive visual loss.

Deep Second Degree Burn of Ferrous Chloride in a Worker at a Wastewater Treatment Facility

FeCl₂ is often used in stainless steel surface processing, wastewater treatment, or in laboratories. Effects of exposure to FeCl₂ include predominantly systemic side effects that can occur when inhalation or oral intake occurs. However, it is known that skin irritation or burning can be caused by exposure to skin, but there has never been reported a case of deep FeCl₂ burns. We will introduce a case of a patient treated with deep second degree burn due to FeCl₂ exposure. A 27-year-old healthy man came in contact with FeCl₂ on his right wrist. The patient didn't wear any protective clothing, and the clothes were contaminated with FeCl₂ about one hour ago, but the patient was not aware of the danger of exposure. After an hour, the patient felt tingling, so he took off his exposed clothes and washed exposed skin, then came to our hospital. Initially there were mild erosion, erythema, and tingling symptoms. Two days later, eschar began to develop and wound began to deepen. Surgical procedure was not performed and it took 5 weeks for the patient's wound to heal. As a rule, workers using FeCl₂ are required to wear protective clothing. In Korea, companies and laboratories using FeCl₂ are not strictly required the use of protective clothing. Workers handling FeCl₂ should be strictly encouraged to wear protective clothing, if exposed, should be instructed to visit the hospital after a quick washing away.

Detergent Solution-induced Alkaline Burn of Hand: A Case Report and Review of Literature

We present an interesting case of arbitrary chemical burn resulting from exposure to an undiluted detergent solution as a folk remedy. A 59-year-old woman came to the emergency department presenting chemical burn on her hand. She was affected by housewife's eczema on her left hand and wanted to cure the lesion. So three days before she came to hospital, she had put her hand into an undiluted detergent solution for an hour as a folk remedy for eczema. The patient was treated with foam dressing while the wound was demarcated. After three weeks, she underwent full-thickness skin graft on her 4(th) finger only. On postoperative day 14, the grafted skin was well-taken and on postoperative day 32, the wound was healed completely with a nail growth. Dish detergent solution has been widely used in kitchen but there is no documented report of chemical burn resulting from a detergent solution. When this patient came to our hospital at first time, the wound was so inflammatory and partial necrosis was combined. So we waited for demarcation preparing even for amputation. But with application of appropriate foam dressing, the patient was healed well and required only partial skin graft. We may encounter the patients suffer from the chemical burns due to usual detergent sometimes. But we do not need to perform surgical treatment immediately. Instead, appropriate dressing will be helpful to minimize operation range.

Caracterización de las quemaduras por sustancias químicas en el Hospital Universitario de Santander, Bucaramanga, Colombia, entre 2009 y 2014 / Characterization of chemical burns at the Hospital Universitario de Santander, Bucaramanga, Colombia, between 2009 and 2014

las quemaduras por sustancias químicas son consideradas lesiones graves por su alto potencial de causar daño local y sistémico,representan entre el 2,4% y el 10,7% de los pacientes admitidos en las unidades de quemados, con una mortalidad asociada del 30%.La literatura disponible en latinoamérica es escasa. Objetivo: el objetivo del estudio es determinar las características clínicas y epidemiológicas de los pacientes con quemadurasquímicas atendidos en la Unidad de Quemados del Hospital Universitario de Santander, Bucaramanga, Colombia. Materiales y métodos: se realizó un estudio de tipo observacional,descriptivo, retrospectivo, en el cual se incluyeron los pacientes que presentaron quemaduras por agentes químicos entre el 1 de enero de 2009 hasta 31 de diciembre de 2014; se incluyeron 29 pacientes. Resultados: las quemaduras químicas representaron el 1,5% de todas las quemaduras;predominio en el género masculino 17 casos;todas con una profundidad grado II y III; las extensiones no superaron el 25% de la superficie corporal total; el sitio anatómico más comprometido fue el miembro superior; hubo mayor asociación con accidentes de tipo laboralcon 16 casos; los ácidos como el principal agente químico implicado con 17 casos y 5 lesiones por agresión; 19 ameritaron manejo quirúrgico. Conclusiones: las quemaduras por sustancias químicas representan un porcentaje pequeño pero significativo de las quemaduras, existiendo una clara asociación a situaciones accidentales por falta de capacitación en la manipulación adecuada de sustancias químicas, lo que plantea la necesidad de tomar medidas de prevención primaria...

Chemical Burns are serious injuriesdue to their high potential to cause local andsystemic damage. They represent between 2.4%and 10.7% of the patients admitted to burn units,and have an associated mortality of 30%. Theavailable literature on Latin America is scarce.Objective: the main objective of the study is todetermine the epidemiological and clinicalcharacteristics of patients with chemical burnstreated at Hospital Universitario de Santander burnunit, in Bucaramanga, Colombia. Methods: thiswas an observational, descriptive, andretrospective study, which included patients whopresented with burns by chemical agents betweenJanuary 1, 2009 to December 31, 2014; 29patients were included. Results: chemical burnsaccounted for 1.5% of all burns; 17 cases weremale gender; all were II and III degree burns; totalbody surface did not exceed 25%. The mostaffected site was the upper limb; there was agreater association with work related accidentswith 16 cases; acids were the principal chemicalagent involved with 17 cases and there wasencountered 5 injuries by assault; 19 patientsrequired surgical intervention. Conclusions:chemical burns represent a small but significantpercentage of burns, there is a clear association toaccidental situations due to lack of training in theproper handling of chemicals, raising the need forprimary prevention measures...

A Clinical Analysis of Patient Exposure to Sulfuric Acid Injured

PURPOSE: This study was conducted to identify the characteristics associated with sulfuric acid injury in the emergency department. METHODS: Data were collected retrospectively from January 2007 to December 2015 on all sulfuric acid injuries presenting to the emergency department in Gu-mi Soonchunhyung University Hospital. Patients injured by sulfuric acid were recorded over a nine year study period and collected data included demographics, injury mechanism, injured body part, hospital care and final diagnosis. RESULTS: A total of 26 cases were identified. Most patients were male (88.5%) and the face was the most commonly injured body part. The most common mechanism of injury was splashing injury. A total of 16 (61.5%) patients were identified as having lesions worse than second degree burns. CONCLUSION: Sulfuric acid can cause severe and fatal skin burn. When working with sulfuric acid, acid proof protect clothing, goggles and glove should be worn. Furthermore, safety education and workplace environment improvement are necessary to reduce sulfuric acid injury.

Clinical observation on fresh amniotic membrane transplantation in acute ocular chemical burns / 国际眼科杂志(Guoji Yanke Zazhi)

AIM:To observe the effect of fresh amniotic membrane transplantation ( FAMT) in acute ocular chemical burns. ●METHODS:A prospective study of 25 consecutive cases (36 eyes) with acute ocular chemical burns were treated with FAMT. The clinical efficacy was observed such as the time of amniotic membrane absorbed, corneal epithelialization & transparency, visual acuities and complications. ●RESULTS: With follow-up ranged from 3 to 6mo, 31 eyes′ amniotic membrane were dissolved in 2wk (86%). A total of 33 eyes showed corneal epithelialization in 4wk ( 92%) , 3 eyes showed persistent corneal epithelial defects and need secondary limbal stem cell transplantation or corneal transplantation ( 8%) . A total of 10 eyes showed superficial corneal vascularization (28%), 6 eyes′ cornea were opacity in part (17%), and one eye was symblepharon (3%). ●CONCLUSION:Early FAMT is an effective treatment in the management of acute ocular chemical burns to support epithelial healing, restore ocular surface integrity with potential to improve vision and reduce the incidence of complications. Furthermore, FAMT has advantages of easily obtain and convenient usage, which is suitable in local hospital of our country.

Bone Marrow-derived Mesenchymal Stem Cells Affect Immunologic Profiling of Interleukin-17-secreting Cells in a Chemical Burn Mouse Model

PURPOSE: This study investigated interleukin (IL)-17-secreting cell involvement in sterile inflammation, and evaluated the effect of mesenchymal stem cells (MSCs) on IL-17-secreting cell immunologic profiling. METHODS: Twenty mice were sacrificed at time points of 6 hours, 1 day, 1 week, and 3 weeks (each group, n = 5) after the cornea was chemically injured with 0.5N NaOH; IL-17 changes in the cornea were evaluated using enzyme-linked immunosorbent assay. Further, IL-17 secreting cells were assessed in the cervical lymph nodes by a flow cytometer. Rat MSCs were applied intraperitoneally in a burn model (n = 10), IL-17-secreting T helper 17 (Th17) cell and non-Th17 cell changes were checked using a flow cytometer in both cornea and cervical lymph nodes at 1week, and compared with those in the positive control (n = 10). RESULTS: IL-17 was highest in the cornea at 1 week, while, in the cervical lymph nodes, IL-17-secreting cells showed early increase at 6 hours, and maintained the increase through 1 day to 1 week, and levels returned to the basal level at 3 weeks. Specifically, the non-Th17 cells secreted IL-17 earlier than the Th17 cells. When the MSCs were applied, IL-17 secretion was reduced in CD3(+)CD4(-)CD8(-), CD3(+)CD4(+)CD8(-), and CD3(+) CD4(-)CD8(+) cells of the cervical lymph nodes by 53.7%, 43.8%, and 50.8%, respectively. However, in the cornea, IL-17 secretion of CD3(+)CD4(-)CD8(-) cells was completely blocked. CONCLUSIONS: The results indicated that both IL-17-secreting non-Th17 and Th17 cells were involved in the chemical burn model, and MSCs appeared to mainly modulate non-Th17 cells and also partially suppress the Th17 cells.

Paediatric ocular trauma admissions to the University Hospital of the West Indies 2000-2005 / Ingresos por trauma ocular pediátrico en el Hospital Universitario de West Indies 2000-2005

PURPOSE: To assess the epidemiology of paediatric ocular trauma presenting to the University Hospital of the West Indies (UHWI), Jamaica, between January 2000 and December 2005. METHODS: Retrospective review of all paediatric patients (< 16 years old) admitted with ocular trauma in the UHWI trauma database. RESULTS: Three hundred and ninety-seven patients were admitted with ocular trauma during the study period, 36.5% of admissions were < 16 years old. Males comprised 69.6% (101/145) of the paediatric admissions. The mean age was 8.3 years (95% CI 7.2, 9.4) and 8.7 years (95% CI 7.9, 9.4) for the females and males, respectively. The commonest place of injury was in the home: 47.5% and 50% in males and females, respectively. Females were more likely to be involved in domestic disputes (4.8%). Stones (20.3%) were the most common causative agent of eye injury in children, only occurring in the 4-16-year old age group. The highest incidence for hospitalization of paediatric eye injury occurred in March and May, with the least admissions occurring in February. Contusions (48.3%) were the most common type of injury. Open globe injuries occurred in 35.9% of cases. Chemical burns were the least common type of injury. The admission period ranged from 1-58 days. The median hospitalization period was five days (95% CI 4.5, 6.0). CONCLUSION: Paediatric ocular injury can be age specific. Contusion was the most common ocular injury and males were more likely to be hospitalized than females. Epidemiological information is important in determining the burden of ocular disease in the population. It is also essential in planning improvement in health services and patient education for prevention of serious eye injuries.

OBJETIVO: Evaluar la epidemiología del trauma ocular pediátrico en el Hospital Universitario de los Indias Orientales (UHWI), Jamaica, entre enero de 2000 y diciembre de 2005. MÉTODOS: Revisión retrospectiva de todos los pacientes pediátricos (<16 años de edad) ingresados con trauma ocular, según la base de datos del HUWI. RESULTADOS: Trescientos noventa y siete pacientes con trauma ocular fueron ingresados en el periodo bajo estudio; 36.5% de los ingresos tenían < 16 años de edad. Los varones comprendían el 69.6% (101/145) de los ingresos pediátricos. La edad promedio fue de 8.3 años (95% CI 7.2, 9.4) y 8.7 años (95% CI 7.9, 9.4) para las hembras y los varones, respectivamente. El lugar más común del accidente traumático fue la casa: 47.5% y 50% en los varones y las hembras, respectivamente. Las hembras presentaban una mayor probabilidad de estar involucradas en disputas domésticas (4.8%). Las piedras (20.3%) fueron el agente causante más común de la lesión del ojo en los niños, ocurriendo solamente en el grupo de 4-16 años de edad. La incidencia más alta de hospitalización por lesión ocular pediátrica ocurrió en marzo y mayo, siendo febrero el mes de menores ingresos. Las contusiones (48.3%) fueron el tipo más común de lesión. Las lesiones abiertas del globo ocular tuvieron lugar en 35.9% de los casos. Las quemaduras químicas fueron el tipo menos común de lesión. El periodo de ingreso osciló de 1-58 días. El periodo promedio de hospitalización fue de cinco días (95% CI 4.5, 6.0). CONCLUSIÓN: La lesión ocular pediátrica puede ser específica por edad. La contusión fue la lesión ocular más común, y la probabilidad de hospitalización fue más alta en los varones que en las hembras. La información epidemiológica es importante a la hora de determinar la carga de la enfermedad ocular sobre la población. También resulta fundamental cuando se trata de planificar el mejoramiento de nuestros servicios de salud y la educación de los pacientes para prevenir lesiones oculares serias.

Hospitalization trends in adult ocular trauma at the University Hospital of the West Indies / Tendencias de la hospitalización por trauma ocular adulto en el Hospital Universitario de West Indies

OBJECTIVE: To assess the epidemiology of ocular trauma in adult patients admitted to the University Hospital of the West Indies (UHWI), Jamaica, between January 2000 and December 2005. METHODS: Retrospective review of all adult patients admitted with ocular trauma in the UHWI trauma database. RESULTS: Three hundred and ninety-seven patients were admitted with ocular trauma during the study period; 35.8% of admissions with ocular trauma were < 16 years of age. There were 252 adults (>17 years old); 21.4% (54/252) were females and 78.6% (198/252) were males. The ratio of males to females was 3.7:1. The median age of the females and males was 32 years (95% CI 27, 35.9) and 33 years (95% CI 30, 35.0), respectively. The hospitalization period ranged from 1-283 days, mean 8.8 days in the males; and ranged from 1-39 days, mean six days in the females. March had the highest mean admissions over the six years. Severe chemical burns were the cause of the longest admissions. The most common place of injury was the home (30.2%) followed by in the street (28.2%); only 2% were from recreation. The most common cause of ocular injury was motor vehicle accident in 18.6%. The second most common cause was from nail hammering (14.3%); of this, 97.2% were male. Females (14.8%) were more commonly admitted from chemical injuries than males (11.1%). Of the females, 50% were due to domestic dispute and 50% were accidental bleach spills. CONCLUSION: The most common cause of ocular injury was motor vehicle accidents, nail hammering in males and chemical injuries in females. Epidemiological information is important in determining the burden of ocular disease on the population. It is essential in planning improvement in health services and patient education for prevention ofserious eye injuries.

OBJETIVO: Evaluar la epidemiología del trauma ocular en pacientes adultos ingresados en el Hospital Universitario de West Indies (UHWI), Jamaica, entre enero de 2000 y diciembre de 2005. MÉTODOS: Se llevó a cabo una revisión retrospectiva de todos los pacientes adultos ingresados por trauma ocular en el HUWI, de acuerdo con la base de datos de dicho centro hospitalario. RESULTADOS: Trescientos noventa y siete pacientes fueron ingresados con trauma ocular en el periodo del estudio; 35.8% de los ingresos por trauma ocular tenían <16 años de edad. Se trataba de 252 adultos (>17 años de edad); 21.4% (54/252) eran hembras y 78.6% (198/252) eran varones. La proporción de varones con respecto a las hembras fue 3.7:1. La edad promedio de hembras y varones fue 32 años (95% CI 27, 35.9) y 33 años (95% CI 30, 35.0), respectivamente. El periodo de hospitalización osciló de 1 - 283 días, con una media de 8.8 días para los varones; y fluctuó de 1-39 días, con una media de 6 días, para las hembras. Marzo presentó el mayor promedio de ingresos durante los seis años. Las quemaduras químicas severas constituyeron la causa de los ingresos de mayor estadía. El lugar más común de ocurrencia de las lesiones fue la casa (30.2%), seguido por la calle (28.2%); sólo 2% fueron lugares de recreación. La causa más común de lesión ocular fueron los accidentes motovehiculares en 18.6%. La segunda causa más común provino de martillar clavos (14.3%); de éstos, 97.2% fueron varones. Las hembras (14.8%) fueron más comúnmente ingresadas a causa de lesiones por sustancias químicas, en comparación con los varones (11.1%). De las hembras, 50% de los casos se debieron a disputas domésticas, y 50% a derramamientos accidentales de lejía. CONCLUSIÓN: La causa más común de la lesión ocular fueron los accidentes motovehiculares y el martilleo de clavos en los hombres, y las lesiones por sustancias químicas en las hembras. La información epidemiológica es importante a la hora de determinar la carga de las enfermedades oculares sobre la población. La misma es fundamental para planificar el mejoramiento de los servicios de salud y la educación de los pacientes en la prevención de lesiones oculares.

Hydrofluoric Acid Burns: A Case Report / 대한산업의학회지

BACKGROUND: Hydrofluoric acid_(HF) is widely used in many industrial and domestic settings such as etching glass, and polishing metals. HF is one of the most corrosive inorganic acids and can produce progressive and serious tissue necrosis with severe pain. Since HF chemical burns can be asymptomatic for the first few hours, it is crucial to understand its toxicity and the early use of antidote. CASE: A 37-year-old man presented with erythematous lesion and pain on his face, anterior neck, both forearms, both thighs, and left ankle after injury resulting from a chemical burn caused by HF. He showed normal vital signs and dyspnea, but complained of a sore throat. Liquid form of HF had splashed on his face and anterior neck first and run down his forearms and thighs while working at HF supply tanks. Some of the HF was splashed into his mouth. He immediately removed his clothes and showered with abundant water. A 4.5% calcium gluconate jel was applied to the involved area. He was given subcutaneous injection of 10% calcium gluconate solution. During 17 days of admission he didn't show any signs of systemic intoxication or deep tissue defects. CONCLUSIONS: Immediate cleansing of the affected area with running cold water is the first critical treatment for a chemical burn due to HF. Applying calcium gluconate gel within one hour was very effective for preventing further damage to the injured area as well as systemic injury. In order to reduce the risk of accident and perform first-aid treatment quickly, it is imperative to provide workers with safety education and establish safety facilities.

The Effect of Amniotic Membrane Transplantation in Severe Chemical Burns / 医学研究杂志

Objective To investigate the efficacy and safety of amniotic membrane transplantation in the treatment of severe chemical burns.Methods Amniotic membrane transplantation were performed in 41 patients(41eyes)suffered with severe chemical burns,in which 26 cases were alkaline burns,15 cases were acid burns.Results 41 cases were followed up about 6-24 months,the effective rate were 92.7%,alkaline burns were 92.3%,acid burns were 93.3%.Conclusions Amniotic membrane transplantation is an effective and safe method for the treatment of chemical burns.

Clinical study of reversed lamellar keratoplasty / 眼科新进展

Objective　To evaluate the therapeutic efficiency of reversed lamellar keratoplasty for bullous keratopathy, Terrien's marginal degeneration and ocular chemical burns.Methods　Twenty eyes of patients with bullous keratopathy, twelve eyes with Terrien's marginal degeneration, ten eyes with chemical burns were recruited in this study.Diseased tissues were removed by means of dissection.Reversed lamellae corneal tissues which had been prepared by cryopreservation were thawed and rinsed. Then the prepared posterior corneal lamellae was turned over, endothelium facing upwards. The diameter of the graft should be 0.5～1.0mm larger than that of the recipient bed. The reversed donor posterior lamellae was sutured into the host keratectomy bed with 10-0 nylon sutures continuously or interruptedly.Results　Allograft reaction episode occurred only one (chemical burn) of the total 42 eyes enrolled.The grafts of the rest 41 eyes maintained clear or semitransparent for 1～5 years. Graft edema could be observed within 2～4 weeks postoperatively. Postoperative interface separation was not found. For all 20 patients with bullous keratopathy, the symptoms of pain disappeared. The visual acuity improved 2～3 lines of Snellen among eleven of twelve patients with Terrien's marginal degeneration. The visual acuity improved 2～3 lines of Snellen with four patients with chemical burns.Conclusion　The technique of reversed lamellar keratoplasty can be applied successfully for tectonic reconstruction of corneal surface such as bullous keratopathy, Terrien' s marginal degeneration and also chemical burns.The effects of therapy was satisfactory.